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HQL-79 is a selective inhibtor of hematopoietic prostaglandin D (PGD) synthase, one of two synthases involved in the production of Prostaglandin D2 (PGD2) from arachidonic acid. HQL-79 selectively inhibited the activity of recombinant H-PGDS with an IC50 of 6 μM and had almost no effect on COX-1, COX-2, m-PGES, or L-PGDS up to 300 μM. HQL-79 has anti-inflammatory activity in vitro and in vivo. HQL-79 is antiallergic and anti-inflammatory. HQL-79 displays antiasthmatic activity and potent antihistaminic properties in vivo. HQL-79 is a synthetic tetrazole compound originally prepared as a possible antihistamine. Subsequent evaluation in models of allergy and asthma demonstrates the HQL-79 inhibits the synthesis of PGD2. HQL-79 is thus a likely lead compound for the preparation of potent, selective PGE synthase inhibitors.
| Molecular Weight | 377.48 |
| Formula | C22H27N5O |
| CAS Number | 162641-16-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 2 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PGE synthase Products |
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| MF63
MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme respectively. |
| Benzydamine hydrochloride
Benzydamine hydrochloride is a topical nonsteroidal anti-inflammatory compound (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity. |
| Sinensetin
Sinensetin is a methylated flavonoid found in fruits that has strong anti-vascular and anti-inflammatory properties. |
| SAR191801
hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay. |
| Zomepirac sodium salt
Zomepirac Sodium is a pyrrole-acetic acid structurally related to tolmetin sodium; a prostaglandin synthetase inhibitor. |
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