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HMGB1-IN-1 inhibits the HMGB1/NF-κB/NLRP3 pathway and also exhibits strong NO inhibition in RAW264.7 cells with an IC50 value of 15.9 ± 0.6 μM. anti-inflammatory activity.
| Molecular Weight | 1042.22 |
| Formula | C57H75N3O15 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related HMGB1 Products |
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| Ammonium Glycyrrhizinate
Ammonium Glycyrrhizinate is a unique product derived from Licorice root and has an extremely sweet taste. |
| Glycyrrhizic acid
Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root. Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities. |
| Dipotassium glycyrrhizinate
Dipotassium glycyrrhizinate is a HMGB1 inhibitor, inhibits atopic dermatitis-related gene expression with anti-anti-inflammatory activity. |
| NecroX-7
NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research. |
| Inflachromene
Inflachromene, a microglial inhibitor, binds to HMGB1 and HMGB2 and exerts anti-inflammatory effects. Inflachromene effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage. Inflachromene can be used for the research of neuroinflammatory disorders. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
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