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HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 with an IC50 of 165 nM. HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation.
| Molecular Weight | 580.62 |
| Formula | C29H27F3N6O2S |
| CAS Number | 2222354-57-4 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Related IRAK Products |
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| CA-4948
CA-4948 is a selective, potent and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) that regulates IRAK4 function in the TLR and IL-1R signaling cascades. CA-4948 has good pharmacokinetic characteristics and antitumor activity in vitro and in vivo. |
| AS 2444697
AS 2444697 is a potent and selective IRAK4 inhibitor. |
| Zimlovisertib
PF06650833 (Zimlovisertib) is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4). |
| IRAK-1-4 Inhibitor I
IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.3 μM and 0.2 μM, respectively. |
| Zabedosertib
Zabedosertib (BAY 1834845) is a selective, orally potent IRAK4 inhibitor with immunomodulatory and anti-inflammatory activity and an IC50 value of 3.55 nM. Zabedosertib (BAY 1834845) exhibits anti-inflammatory property against IL-β, LPS and Imiquimod induced inflammation. |
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