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Hexa-D-arginine

Cat. No. M14816

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Hexa-D-arginine Structure
Synonym:

Furin Inhibitor II

Size Price Availability Quantity
1mg USD 70 In stock
5mg USD 200 In stock
10mg USD 320 In stock
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Quality Control & Documentation
Biological Activity

Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo.

Chemical Information
Molecular Weight 954.14
CAS Number 673202-67-0
Solubility (25°C) Water 50 mg/mL
DMSO 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Baozhi Yuan, et al. Hexa-D-arginine treatment increases 7B2•PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype

[2] Rod Balhorn, et al. Hexa-arginine enhanced uptake and residualization of selective high affinity ligands by Raji lymphoma cells

[3] Erki Enkvist, et al. Conjugation of adenosine and hexa-(D-arginine) leads to a nanomolar bisubstrate-analog inhibitor of basophilic protein kinases

[4] Miroslav S Sarac, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo

[5] Miroslav S Sarac, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo

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Keywords: Hexa-D-arginine, Furin Inhibitor II supplier, Peptides, inhibitors, activators

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