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Hesperetin is a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin exhibits strong inhibitory effects on UGT1A1, 1A3 and 1A9 (both IC50 and Ki values lower than 10 µM) and moderately inhibits UGT1A4, UGT1A7, UGT1A8 (IC50 values 29.68-63.87 µM). Hesperetin dose-dependently reduces GCDCA-induced caspase-3 activity in cultured primary rat hepatocytes. Hesperetin also dose-dependently reduces CM-induced Nos2 (iNOS) expression in hepatocytes.
Hesperetin (200 mg/kg) attenuates Con A-induced hepatocyte apoptosis and hepatic Nos2 (iNOS) expression in mice. Hesperetin co-treatment also decreases the occurrence of apoptotic bodies, hydropic degeneration, nuclear fragments, autolysis and haemorrhage. The number of leukocytes infiltrated in liver tissue of mice with D-GalN/LPS-induced fulminant hepatitis are significantly decreased by hesperetin in a murine model.
Chinese Journal of Clinical Pharmacology and Therapeutics. 2024 Oct 24.
Hesperetin induces apoptosis in gefitinib-resistant NCI-H1975 cells through ROS mediated endoplasmic reticulum stress
Hesperetin purchased from AbMole
| Molecular Weight | 302.28 |
| Formula | C16H14O6 |
| CAS Number | 520-33-2 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
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Products are for research use only. Not for human use. We do not sell to patients.
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