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Hepcidin-25 (human) is an iron metabolism modulator. Hepcidin-25 (human) shows anti-inflammatory and anti-bacterial activity via modulation of iron-mediated oxidant injury.
| Cell Experiment | |
|---|---|
| Cell lines | The C. albicans SC5314 strain |
| Preparation method | The effect of hep 25 on the integrity of the C. albicans plasma membrane was determined by measuring the leakage of calcein from small unilamellar liposome vesicles. The SUVs were composed of phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI) and ergosterol in a ratio of 5:4:1:2 (w/w/w/w) and were prepared as previously described with some modifications. The SUVs were treated with various concentrations (0, 6.25, 12.5, 25 and 50 μg/mL) of hep 25 at room temperature (RT). |
| Concentrations | 0, 6.25, 12.5, 25 and 50 μg/mL |
| Incubation time | 90 min |
| Animal Experiment | |
|---|---|
| Animal models | C57/Bl6J mice |
| Formulation | PBS |
| Dosages | 0, 5, 15.8, and 50 μg/mouse |
| Administration | Intraperitoneal injection |
| Molecular Weight | 2789.35 |
| Formula | C113H170N34O31S9 |
| CAS Number | 1356390-47-0 |
| Storage | -20°C, protect from light, sealed |
| Related Metabolite/Endogenous Metabolite Products |
|---|
| 2'-Deoxyinosine
2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability. |
| Ribitol
Ribitol (Adonitol) is a crystalline pentose alcohol formed by the reduction of ribose. |
| Glycodeoxycholic Acid
Glycodeoxycholic Acid is an endogenous metabolite. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis. |
| Glycolithocholic acid
Glycolithocholic acid, an endogenous metabolite, is a glycine conjugated secondary bile acid. Glycolithocholic acid can be used to study ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH0) and primary sclerosing cholangitis (PSC). |
| 4-Aminohippuric Acid
4-Aminohippuric acid is a typical substrate of organic anion transport systems. 4-Aminohippuric acid is a diagnostic agent, useful in medical tests involving the kidney, used in the measurement of renal plasma flow. |
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