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Hematein is an oxidized product of hematoxylin, which can be used as a dye. Hematein is also a modified casein kinase II inhibitor with an IC50 of 0.74 μM, and also inhibits Akt/PKB Ser129 phosphorylation, Wnt/TCF pathway and increases apoptosis in lung cancer cells.
| Molecular Weight | 300.26 |
| Formula | C16H12O6 |
| CAS Number | 475-25-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Harry A Dailey, et al. Biol Chem. A primer on heme biosynthesis
[2] Luděk Kořený, et al. Biol Rev Camb Philos Soc. The convoluted history of haem biosynthesis
[3] Glenn S Gerhard. Curr Nutr Rep. Heme as a Taste Molecule
[4] Yoshihiro Kubo. Pflugers Arch. A new world of heme function
[5] Arianna I Celis, et al. Curr Opin Struct Biol. Making and breaking heme
| Related Casein Kinase Products |
|---|
| Silmitasertib (CX-4945)
CX-4945 (Silmitasertib) is a potent small molecule protein kinase inhibitor that selectively binds to and inhibits the enzyme casein kinase II (CK2). |
| PF-4800567
PF-4800567 is a selective, ATP competitive casein kinase 1ε inhibitor with IC50 values of 32 and 711 nM for CK1ε and CK1δ respectively. |
| D4476
D4476 is a selective inhibitor of casein kinase 1 (CK1) and TGF-β type-I receptor (ALK5) with IC50 of 0.3 µM and 0.5 µM, respectively. |
| TTP 22
TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM. |
| TBB
TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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