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Hederagenin is a triterpenoid saponin. It can inhibit LPS-stimulated expression of iNOS, COX-2, and NF-κB. Hederagenin may be a promising candidate for human colon cancer studies. Hederagenin could significantly inhibit the viability of Lovos cells in a concentration and time-dependent manner with IC50 of 1.39μM at 24 h and 1.17μM at 48 H. Hederagenin could also induce apoptosis by nuclear changes characterized by Hirst 33342 nuclear stainining fluorescence microscopy. Dcfh-da fluorescence staining and flow cytometry showed that Hederagenin could significantly increase the production of ROS in LoVo cells. Real-time PCR results showed that Hederagenin induced up-regulation of Bax expression and down-regulation of Bcl-2, Bcl-XL and Survivin expression. Western blotting showed that Hederagenin reduced the expression of apoptosis-related proteins Bcl-2, Procaspase-9, procaspase-3 and Polyadp-Ribosepolymerase (PARP). Increased the expression of Bax, caspase-3 and caspase-9. However, there was no significant change in caspase-8.
| Molecular Weight | 472.70 |
| Formula | C30H48O4 |
| CAS Number | 465-99-6 |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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