Free shipping on all orders over $ 500

Hederacolchiside-A1

Cat. No. M4117

All AbMole products are for research use only, cannot be used for human consumption.

Hederacolchiside-A1 Structure
Size Price Availability Quantity
5mg USD 200 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Hederacolchiside A1, isolated from Pulsatilla pulsatilla, induces apoptosis by regulating the PI3K/Akt/mTOR signaling pathway, thereby inhibiting the proliferation of tumor cells. Hederacolchiside A1 has anti-schistosomiasis activity and affects parasite viability in vivo and in vitro.

Chemical Information
Molecular Weight 897.10
Formula C47H76O16
CAS Number 106577-39-3
Form Solid
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Naixin Kang, et al. Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis

[2] Yuanying Fang, et al. Synthesis and biological evaluation of Hederacolchiside A1 derivatives as anticancer agents

[3] Mao-Sheng Cheng, et al. Synthesis of beta-hederin and Hederacolchiside A1: triterpenoid saponins bearing a unique cytotoxicity-inducing disaccharide moiety

[4] Chantal Barthomeuf, et al. Inhibition of HUVEC tubulogenesis by hederacolchiside-A1 is associated with plasma membrane cholesterol sequestration and activation of the Ha-Ras/MEK/ERK cascade

[5] E Debiton, et al. In addition to membrane injury, an affinity for melanin might be involved in the high sensitivity of human melanoma cells to hederacolchiside A1

Related PI3K Products
AS605240

AS-605240 is a potent and selective inhibitor of PI 3-kinase γ (PI3Kγ) with an IC50 of 8 nM.

BEZ235

BEZ235 (NVP-BEZ235) is a potent dual PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively.

BKM120 (Buparlisib)

BKM120 (NVP-BKM120) is a potent and highly specific oral pan-class I PI3K inhibitor.

GDC-0941 (Pictilisib)

GDC-0941 is a selective and potent inhibitor of Class I PI3K, p110a IC50=0.003uM, U87MG IC50=0.95μM.

AS-252424

AS-252424 is a furan-2-ylmethylene thiazolidinedione as a selective ATP-competitive PI3Kγ inhibitor with IC50 with 33 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Hederacolchiside-A1 supplier, PI3K, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.