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H3B-8800 is an orally available small molecule modulator of splicing factor 3B subunit 1 (SF3B1). H3B-8800 binds SF3B1 and exhibits significant antitumor activity by eliminating disruption of mRNA splicing.
| Molecular Weight | 555.71 |
| Formula | C31H45N3O6 |
| CAS Number | 1825302-42-8 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | Powder -20°C |
[1] Bryan Oronsky, et al. Invest New Drugs. RRx-001, A novel dinitroazetidine radiosensitizer
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