Free shipping on all orders over $ 500

H-89

Cat. No. M3559

All AbMole products are for research use only, cannot be used for human consumption.

H-89 Structure
Synonym:

Protein kinase inhibitor H-89

Size Price Availability Quantity
50mg USD 260 In stock
100mg USD 440 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

H-89 is a potent and selective inhibitor of PKA, with an IC50 of about 50 nM. H-89 inhibits several other kinases with IC50 of 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b, respectively. H-89 also inhibits PKG and the µ isotype of PKC (at about 500 nM). In contrast, most other PKC isotypes are much more weakly inhibited, with IC50’s in the 32 µM range. Intraperitoneal administration of H-89 (0.2 mg/100g) significantly increased seizure latency and threshold in PTZ-treated animals. H-89 (0.05, 0.2 mg/100g) prevented the epileptogenic activity of bucladesine (300 nM) with significant increase of seizure latency and seizure threshold.

Customer Product Validations & Biological Datas
Source J Appl Oral Sci (2018). Figure 5. H-89
Method Western blotting
Cell Lines mDP cells
Concentrations 10 μM
Incubation Time 6 h
Results CaCl2-induced ERK1/2 phosphorylation was not inhibited in the presence H-89.
Chemical Information
Molecular Weight 446.36
Formula C20H20BrN3O2S
CAS Number 127243-85-0
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kaveh Tabrizian, et al. Tadalafil Reversed H-89 - and Scopolamine - Induced Spatial Learning Impairments in Male Rats

[2] Rojin Sharif, et al. Melatonin reverses H-89 induced spatial memory deficit: Involvement of oxidative stress and mitochondrial function

[3] Randi J Parks, et al. H-89 decreases the gain of excitation-contraction coupling and attenuates calcium sparks in the absence of beta-adrenergic stimulation

[4] Yoshiro Kato, et al. H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A

[5] Siyanda Makaula, et al. H-89, a non-specific inhibitor of protein kinase A, promotes post-ischemic cardiac contractile recovery and reduces infarct size

Related PKA Products
H-89 Dihydrochloride

H-89 dihydrochloride is a selective inhibitor of protein kinase A (PKA) with an IC50 value of 135 nM.
Bucladesine Sodium Salt

Bucladesine, a membrane permeable selective activator of PKA, has a critical role in up-regulation of ChAT and VAChT gene expression in PC12 cells by activation of extracellular signal regulated kinase (ERK) in Ca2+- and PKA-dependent manner.
8-Bromo-cAMP sodium salt

8-Bromo-cAMP is a cell perbeable cyclic AMP (cAMP) analog and a PKA activator.
5-Iodotubercidin

5-IOdotubercidin (NSC 113939), an ATP analogue, is a potent inhibitor of adenosine kinase with an IC50 value of 26 nM. 5-IOdotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by activating phosphorylase and glycogen synthase. 5-IOdotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC, and Haspin inhibitors.
HA-100

Ha-100 is a potent protein kinase inhibitor with IC50 values of 4 μM, 8 μM, 12 μM and 240 μM against PKG, PKA, PKC and MLC kinases, respectively. Ha-100 is also used as a ROCK inhibitor.
  Catalog
Abmole Inhibitor Catalog




Keywords: H-89, Protein kinase inhibitor H-89 supplier, PKA, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.