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GYKI 53655 hydrochloride

Cat. No. M6780

All AbMole products are for research use only, cannot be used for human consumption.

GYKI 53655 hydrochloride Structure

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Biological Activity

GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466. Prolongs the survival time after MgCl2- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations.

Chemical Information
Molecular Weight 388.85
Formula C19H20N4O3.HCl
CAS Number 143692-48-2
Solubility (25°C) Water 38.88 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Raven, et al. J Biol Chem. PKR and PKR-like endoplasmic reticulum kinase induce the protease-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2α phosphorylation.

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