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GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 has anti-inflammatory and anti-atherosclerotic activities. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. GW9508 has anti-inflammatory and anti-atherosclerotic activities.
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Source | Exp Cell Res (2013). Figure 1. GW9508 |
| Method | XTT analyzes | |
| Cell Lines | MC3T3-E1 cell | |
| Concentrations | 1 10 50 100 μM | |
| Incubation Time | 24 h | |
| Results | To determine whether cell growth inhibition was related to cytostatic effects or cell death, OcP were labeled for apoptosis and necrosis pathways as determined by annexin V/7-AAD apoptosis detection kit. According to fluorescent activating cell sorting data, when incubated with 100 mM of GW9508, cells were found positive for both markers |
| Molecular Weight | 347.41 |
| Formula | C22H21NO3 |
| CAS Number | 885101-89-3 |
| Solubility (25°C) | DMSO ≥ 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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