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GW833972A

Cat. No. M7821

All AbMole products are for research use only, cannot be used for human consumption.

GW833972A Structure

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Quality Control & Documentation
Biological Activity

GW833972A is a CB2 cannabinoid receptor agonist with 1000-fold selectivity relative to CB1. It is, however, 15-fold less potent than HU210 for CB2 (Ki 7.8 vs. 0.52 nM). The antitumor compound oxaliplatin induces marked hypersensitivity to cold, heat, and chemical pain stimuli (to the point where oxaliplatin therapy has to be discontinued). The hyperalgesia effect is almost completely blocked by pretreatment with GW833972A.

Chemical Information
Molecular Weight 444.24
Formula C18H13ClF3N5O · HCl
CAS Number 1092502-33-4
Solubility (25°C) DMSO: ≥20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Aylar Alenabi, et al. Cannabinoids pharmacological effects are beyond the palliative effects: CB2 cannabinoid receptor agonist induced cytotoxicity and apoptosis in human colorectal cancer cells (HT-29)

[2] Jakub Mlost, et al. CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development

[3] Gabriel Lpez-Ramrez, et al. D 2 autoreceptor switches CB 2 receptor effects on [ 3 H]-dopamine release in the striatum

[4] Rodolfo Snchez-Zavaleta, et al. Presynaptic cannabinoid CB2 receptors modulate [ 3 H]-Glutamate release at subthalamo-nigral terminals of the rat

[5] M G Belvisi, et al. Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways

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Keywords: GW833972A supplier, inhibitors, activators

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