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GW 405833 is a potent and selective CB2 receptor partial agonist. GW 405833 binds with high affinity to both human and rat CB2 receptors and displays ~ 1200-fold selectivity over CB1 (Ki values are 3.92 and 4772 nM for human recombinant CB2 and CB1 receptors respectively). GW 405833 produces potent antihyperalgesic effects in several rodent models of pain.
| Molecular Weight | 447.35 |
| Formula | C23H24Cl2N2O3 |
| CAS Number | 180002-83-9 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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