Free shipping on all orders over $ 500

Guttiferone G

Cat. No. M38945

All AbMole products are for research use only, cannot be used for human consumption.

Guttiferone G Structure

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla.

Chemical Information
Molecular Weight 670.92
Formula C43H58O6
CAS Number 666174-75-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Aimé Gabriel Fankam et al. Biomed Res Int. Guttiferone BL from the Fruits of Allanblackia gabonensis Induces Mitochondrial-Dependent Apoptosis in PA-1 Ovarian Cancer Cells

[2] Nicholas A McGrath et al. Chem Commun (Camb). An efficient oxidative dearomatization-radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products

[3] Claudia Gey et al. Angew Chem Int Ed Engl. Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2

[4] Russell B Williams et al. Planta Med. A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest

Related Sirtuin Products
Selisistat

Selisistat (EX 527) is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 98 nM.
SRT1720 Hydrochloride

SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway.

Resveratrol

Resveratrol is a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects.

Balsalazide disodium

Balsalazide is an anti-inflammatory compound used to study inflammatory bowel disease and ulcerative colitis.
Sirtinol

Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM, respectively.
  Catalog
Abmole Inhibitor Catalog




Keywords: Guttiferone G supplier, Sirtuin, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.