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GSK984 is an inactive control probe for GSK983, which is an inhibitor of dihydroorotate dehydrogenase (DHODH) with antiviral activity. GSK983 blocks RNA virus replication with EC50 values of 10–40 nM, and also blocks cell proliferation. GSK984 acts by inhibition of dihydroorotate dehydrogenase (DHODH), necesssary for pyrimidine biosynthesis. Exogenous deoxycytidine was able to reduce GSK983 cytotoxicity, allowing cells to synthesize DNA, but still preventing RNA virus replication. GSK983 was active against dengue fever and Venezuelan equine encephalitis viruses. GSK984, the (S)-isomer, is almost 200-fold less active, so would make a good control.
| Molecular Weight | 325.79 |
| Formula | C18H16ClN3O |
| CAS Number | 827591-04-8 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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