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GSK983

Cat. No. M8684

All AbMole products are for research use only, cannot be used for human consumption.

GSK983 Structure

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Biological Activity

GSK983 blocks RNA virus replication with EC50 values of 10–40 nM, and also blocks cell proliferation. GSK983 acts by inhibition of dihydroorotate dehydrogenase (DHODH), necesssary for pyrimidine biosynthesis. Exogenous deoxycytidine was able to reduce GSK983 cytotoxicity, allowing cells to synthesize DNA, but still preventing RNA virus replication. GSK983 was active against dengue fever and Venezuelan equine encephalitis viruses.

Chemical Information
Molecular Weight 325.79
Formula C18H16ClN3O
CAS Number 827591-02-6
Solubility (25°C) DMSO: 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Qi Liu, et al. Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism

[2] Priya Luthra, et al. Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses

[3] Priya Luthra, et al. A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication

[4] Richard M Deans, et al. Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

[5] Robert Harvey, et al. GSK983: a novel compound with broad-spectrum antiviral activity

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Keywords: GSK983 supplier, inhibitors, activators

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