All AbMole products are for research use only, cannot be used for human consumption.
GSK656 is a potent Mtb LeuRS inhibitor, shows potent inhibition of Mtb LeuRS (IC50 = 0.20 μM) and in vitro antitubercular activity (Mtb H37Rv MIC = 0.08 μM). GSK656 is highly selective for the Mtb LeuRS enzyme with IC50 of >300 μM and 132 μM for human mitochondrial LeuRS and human cytoplasmic LeuRS, respectively. In addition, GSK656 exhibits remarkable PK profiles and efficacy against Mtb in mouse TB infection models with superior tolerability over initial leads.
| Molecular Weight | 293.94 |
| Formula | C10H13BClNO4.HCl |
| CAS Number | 2131798-13-3 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Anti-infection Products |
|---|
| BTZ043 Racemate
BTZ043 Racemate (BTZ038, BTZ044) is a decaprenylphosphoryl-b-D-ribose 2-epimerase inhibitor. |
| Cidofovir
Cidofovir (Vistide) is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis. |
| Entecavir Monohydrate
Entecavir Hydrate is a class of antiviral compounds. |
| Oseltamivir
Oseltamivir is a potent and selective inhibitor of influenza virus neuraminidase enzyme. |
| Zanamivir
Zanamivir is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
