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GSK5852

Cat. No. M28183

All AbMole products are for research use only, cannot be used for human consumption.

GSK5852 Structure
Synonym:

GSK2485852

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Quality Control & Documentation
Biological Activity

GSK5852 (GSK2485852) is an HCV NS5B polymerase inhibitor, with an IC50 value of 50 nM. GSK5852 displays antiviral activity and inhibits HCV with EC50s of 3.0 nM (genotype 1a, GT1a) and 1.7 nM (GT1b), respectively.

Chemical Information
Molecular Weight 554.37
Formula C27H25BF2N2O6S
CAS Number 1331942-30-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] David A Wilfret, et al. Clin Pharmacol Drug Dev. A randomized, double blind, dose escalation, first time in human study to assess the safety, tolerability, pharmacokinetics, and antiviral activity of single doses of GSK2485852 in chronically infected hepatitis C subjects

[2] Christian Voitenleitner, et al. Antimicrob Agents Chemother. In vitro characterization of GSK2485852, a novel hepatitis C virus polymerase inhibitor

[3] Andrew Maynard, et al. J Med Chem. Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase

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Keywords: GSK5852, GSK2485852 supplier, Anti-infection, inhibitors, activators

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