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GSK356278 is a potent, selective, orally bioavailable and brain-penetrant inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory activity, and exhibits anxiolytic and cognition-enhancing effects.
| Molecular Weight | 439.53 |
| Formula | C21H25N7O2S |
| CAS Number | 720704-34-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 2.5 mg/mL (ultrasonic) |
| Storage | -20°C, sealed |
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