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GSK3186899

Cat. No. M21395

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GSK3186899 Structure
Synonym:

DDD-853651

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Quality Control & Documentation
Biological Activity

GSK3186899 (DDD-853651) is an inhibitor of CRK12 with an EC50 value of 1.4 μM for L. donovani.

Chemical Information
Molecular Weight 491.53
Formula C19H28F3N7O3S
CAS Number 1972617-87-0
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Emmanuel Broni, et al. Biomolecules. A Molecular Modeling Approach to Identify Potential Antileishmanial Compounds Against the Cell Division Cycle (cdc)-2-Related Kinase 12 (CRK12) Receptor of Leishmania donovani

[2] Michael G Thomas, et al. J Med Chem. Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis

[3] Susan Wyllie, et al. Nature. Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

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Keywords: GSK3186899, DDD-853651 supplier, inhibitors, activators

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