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GSK137647A is a selective FFAR4 (GRP120) agonist for human, Mouse and Rat FFA4 with pEC50 values of 6.3, 6.2 and 6.1, respectively. GSK137647A is shown to provide at least 100-fold selectivity against the panel which included 41 G-protein-coupled receptors. Under high glucose conditions (25 mM), GSK137647A produces a concentration-dependent increase in glucose stimulated insulin secretion. GSK137647A induces insulin secretion and inhibits epithelial ion transport, GSK137647A is related to regulation of glucose homeostasis and anti-inflammatory response. GSK137647A has anti-inflammatory activity.
| Molecular Weight | 305.39 |
| Formula | C16H19NO3S |
| CAS Number | 349085-82-1 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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