All AbMole products are for research use only, cannot be used for human consumption.
In vitro, Grapiprant inhibits [(3)H]PGE(2) binding to both human and rat EP(4) receptors with K(i) of 13 +/- 4 and 20 +/- 1 nM, respectively. Grapiprant is highly selective for the human EP(4) receptor over other human prostanoid receptor subtypes. Grapiprant also inhibits PGE(2)-evoked elevation in intracellular cAMP at the human and rat EP(4) receptors with pA(2) of 8.3 +/- 0.03 and 8.2 +/- 0.2 nM, respectively.
In vivo, oral administration of Grapiprant significantly reduces thermal hyperalgesia induced by intraplantar injection of PGE(2) (ED(50) = 12.8 mg/kg).
| Molecular Weight | 491.61 |
| Formula | C26H29N5O3S |
| CAS Number | 415903-37-6 |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Prostaglandin Receptor Products |
|---|
| Ethamsylate
Ethamsylate is a haemostatic compound, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhesion. |
| Tafluprost
Tafluprost is a fluorinated analog of prostaglandin F2-alpha and a PGF2alpha agonist that may be used in glaucoma-related studies. |
| Terutroban
Terutroban is a selective antagonist of the thromboxane receptor. |
| Prostaglandin E1
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, which induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases. |
| Latanoprost
Latanoprost is a prostaglandin F2α analog as well as a prostaglandin-like selective FP receptor agonist with lipophilic and corneal penetrating properties. In addition, Latanoprost also increases ocular fluid outflow, thereby reducing intraocular pressure, and may be used in studies related to glaucoma. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
