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Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α).
| Molecular Weight | 1882.29 |
| Formula | C99H140N20O17 |
| CAS Number | 11029-61-1 |
| Form | Solid |
| Solubility (25°C) | Water |
| Storage | Store at ≤ -20°C, dry, sealed |
[4] B Roux, et al. Novartis Found Symp. The binding site of sodium in the gramicidin A channel
[5] B Cornell. J Bioenerg Biomembr. Gramicidin A--phospholipid model systems
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