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GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC50 values of 58 nM and 50 nM for human and mouse GPR81, respectively. GPR81 agonist 1 inhibits lipolysis in differentiated 3T3-L1 adipocytes. GPR81 agonist 1 suppresses lipolysis in mice without cutaneous flushing. GPR81 agonist 1 displays remarkable selectivity for GPR81 over GPR109a.
In vivo, GPR81 agonist 1 (100 mg/kg; i.p.) suppresses lipolysis in mice without cutaneous flushing.
J Mol Cell Biol. 2024 May 17;mjae021.
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production
GPR81 agonist 1 purchased from AbMole
| Molecular Weight | 446.63 |
| Formula | C22H30N4O2S2 |
| CAS Number | 1620992-67-7 |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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Products are for research use only. Not for human use. We do not sell to patients.
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