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Go 6983 is a protein kinase C (PKC) inhibitor with IC50 values of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM for PKCα, PKCβ, PKCγ, PKCδ and PKCζ respectively. Go 6983 inhibited intracellular Ca(2+) accumulation, suggesting a mechanism for its vasodilator properties. In vitro, Go 6983 significantly inhibited antigen-induced superoxide release from leukocytes of patients previously sensitized to tree pollen. Go 6983 (100 nM) significantly reduced PMN adherence to the endothelium and infiltration into the myocardium compared with I/R + PMN hearts (P < 0.01), and significantly inhibited superoxide release from PMNs by 90 +/- 2% (P < 0.01). Go 6983 attenuated post-I/R cardiac contractile dysfunction, which may be related in part to decreased superoxide production in the presence of PMNs.
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Source | Immunobiology (2012). Figure 4. Go 6983 |
| Method | Flow cytometry | |
| Cell Lines | Tca8113 cells | |
| Concentrations | 5 μM | |
| Incubation Time | 24 h | |
| Results | As shown in Fig. 4, after PKD2 was inhibited by Gö6983, IFN-γ could not induce the surface expression of PD-L1 on Tca8113. |
| Molecular Weight | 442.51 |
| Formula | C26H26N4O3 |
| CAS Number | 133053-19-7 |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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