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GNF-2

Cat. No. M2571

All AbMole products are for research use only, cannot be used for human consumption.

GNF-2 Structure
Size Price Availability Quantity
5mg USD 75 In stock
10mg USD 125 In stock
25mg USD 265 In stock
50mg USD 450 In stock
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Quality Control & Documentation
Biological Activity

GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, shows no activity to Flt3-ITD, Tel-PDGFR, TPR-MET and Tel-JAK1 transformed tumor cells.

Chemical Information
Molecular Weight 374.32
Formula C18H13F3N4O2
CAS Number 778270-11-4
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Gyun Jee Song, et al. A Bcr-Abl Inhibitor GNF-2 Attenuates Inflammatory Activation of Glia and Chronic Pain

[2] Margaret J Clark, et al. GNF-2 Inhibits Dengue Virus by Targeting Abl Kinases and the Viral E Protein

[3] Hyun-Ju Kim, et al. The tyrosine kinase inhibitor GNF-2 suppresses osteoclast formation and activity

[4] Mamduh Khateb, et al. Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism

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Keywords: GNF-2 supplier, Src-bcr-Abl, inhibitors, activators

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