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GNE-149

Cat. No. M21273

All AbMole products are for research use only, cannot be used for human consumption.

GNE-149 Structure

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Quality Control & Documentation
Biological Activity

GNE-149 is an efficient monovalent degrader and full antagonist of estrogen receptor alpha with significant oral bioavailability in higher species.

Chemical Information
Molecular Weight 503.57
Formula C28H33F4N3O
CAS Number 1953132-75-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jason R Zbieg, et al. Bioorg Med Chem Lett. Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer

[2] Jun Liang, et al. ACS Med Chem Lett. Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer

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Keywords: GNE-149 supplier, Estrogen Receptor, inhibitors, activators

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