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GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM. GNE-131 shows excellent potency, good in vitro metabolic stability.
In vivo, GNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain.
| Molecular Weight | 442.57 |
| Formula | C23H30N4O3S |
| CAS Number | 1629063-81-5 |
| Solubility (25°C) | DMSO: ≥ 90 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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