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GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays.
| Molecular Weight | 345.48 |
| Formula | C21H31NO3 |
| CAS Number | 1241902-40-8 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | 4°C, dry, sealed |
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