All AbMole products are for research use only, cannot be used for human consumption.
Ilomastat (GM6001; Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor with Ki values of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM and 0.36 nM for MMPs -1, -2, -3, -7, -8, -9, -12, -14 and -26, respectively. Galardin (GM6001) reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. GM6001 also inhibits human skin fibroblast collagenase (Ki = 0.4 nM). GM6001 (Galardin) treatment also inhibited extracellular signal-regulated kinase (ERK) activation induced by bombesin or LPA. In addition, GM6001 inhibited bombesin- or LPA-induced DNA synthesis in a dose dependent manner, when stimulated by increasing concentrations of bombesin, and when added after bombesin stimulation.
Elife. 2020 Sep 28;9:e56006.
The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo
Ilomastat purchased from AbMole
BioRxiv. 2020 Apr 02;22228.
The dynamic interplay between ATP/ADP levels and autophagy sustain neuronal migration in vivo
Ilomastat purchased from AbMole
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Source | Oncotarget (2017). Figure 3. GM6001 |
| Method | RT-PCR | |
| Cell Lines | SCC-9 cells | |
| Concentrations | 10 μM | |
| Incubation Time | 24 h | |
| Results | Suppression of MMP-9 expression by MMP-9 shRNA or GM6001 resulted in a significant reduction of the migration and invasion of CAIX-overexpressing SCC-9 cells |
| Molecular Weight | 388.46 |
| Formula | C20H28N4O4 |
| CAS Number | 142880-36-2 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related MMP Products |
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| Batimastat
Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. |
| NSC 405020
NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP. |
| Marimastat
Marimastat (BB-2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. |
| Apigenin 7-O-glucuronide
Apigenin 7-O-glucuronide is an inhibitor of Matrix Metalloproteinases (MMP) with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively. |
| 20(R)-Ginsenoside Rh2
20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as an anti-proliferative agent in cells. It has anticancer effects by blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis and has anti-inflammatory and antioxidant activities. 20(R)-Ginsenoside Rh2 inhibited the replication and proliferation of mouse and human γ herpevirus 68 (MHV-68) with an IC50 of 2.77 μM against mouse MHV-68. |
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