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Glypromate acetate is a neuroactive peptide with a potent action on acetylcholine release. Glypromate acetate is a weak NMDA receptor agonist binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM.
Glypromate (0-100 μM) potentiates the potassium evoked release of both acetylcholine and dopamine, increases K+ evoked acetylcholine release even at concentrations of 0.1 nM and significantly enhances evoked dopamine release.
In vivo, Glypromate (300 mg; i.p. once per day; on day 0, 6 and 12) shows an in vivo effect protecting the temporal cortical somatostatinergic system from Abeta insult. Glypromate acetate can be used for the research of neuroprotection.
| Molecular Weight | 361.35 |
| Formula | C14H23N3O8 |
| CAS Number | 32302-76-4 (free base) |
| Solubility (25°C) | Water 1 mg/mL DMSO 3 mg/mL |
| Storage | -20°C, dry, sealed |
| Related NMDA Products |
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| Dizocilpine
Dizocilpine (MK-801) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM. |
| D-Cycloserine
D-Cycloserine is an analog of the amino acid D-alanine. |
| D-AP5
D-AP5 is a potent, selective NMDA antagonist. |
| Homoquinolinic acid
Homoquinolinic acid is a selective, potent NMDA agonist. |
| Ibotenic acid
Ibotenic acid is a non-selective NMDA agonist. Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. |
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