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Glycerol phenylbutyrate

Cat. No. M21001

All AbMole products are for research use only, cannot be used for human consumption.

Glycerol phenylbutyrate Structure
Synonym:

GT4P, HPN-100M, Ravicti

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Quality Control & Documentation
Biological Activity

Glycerol phenylbutyrate (GT4P, HPN-100M, Ravicti) is a nitrogen-binding agent and acts as a sigma-2 (σ2) receptor ligand with a pKi of 8.02. Glycerol phenylbutyrate is a prodrug in which phenylbutyrate (PBA) is released from the glycerol backbone by lipases in the gastrointestinal tract.

Chemical Information
Molecular Weight 530.65
Formula C33H38O6
CAS Number 611168-24-2
Solubility (25°C) Water 0 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Marion Almes, et al. J Pediatr Gastroenterol Nutr. Glycerol Phenylbutyrate Therapy in Progressive Familial Intrahepatic Cholestasis Type 2

[2] Johannes Hberle, et al. J Inherit Metab Dis. Suggested guidelines for the diagnosis and management of urea cycle disorders: First revision

[3] No authors listed. Glycerol Phenylbutyrate (Ravicti) [Internet]

[4] Kavish R Patidar, et al. Clin Gastroenterol Hepatol. Covert and Overt Hepatic Encephalopathy: Diagnosis and Management

[5] No authors listed. Med Lett Drugs Ther. Glycerol phenylbutyrate (Ravicti) for urea cycle disorders

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Keywords: Glycerol phenylbutyrate, GT4P, HPN-100M, Ravicti supplier, inhibitors, activators

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