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Glucosylceramide-IN-2 (T-690) is a potent, blood-brain barrier-transparent and orally active inhibitor of glucosylceramide synthase (GCS) with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively. basal and non-competitive with UDP-glucose.
| Molecular Weight | 447.41 |
| Formula | C22H20F3N3O4 |
| CAS Number | 2597958-02-4 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Maria C Messner, et al. Adv Exp Med Biol. Glucosylceramide in humans
| Related Glucosylceramide Synthase Products |
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Eliglustat inhibits glucosylceramide synthase (GCS), thus reducing the load of glucosylceramide influx into the lysosome. |
| Miglustat
Miglustat(OGT918) is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1). |
| Ibiglustat
Ibiglustat (Venglustat) is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. |
| Miglustat hydrochloride
Miglustat hydrochloride also known as OGT 918 and NB-DNJ, inhibits glucosylceramide synthase, and is used primarily to treat Type I Gaucher disease (GD1). |
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