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GLPG1205

Cat. No. M13988

All AbMole products are for research use only, cannot be used for human consumption.

GLPG1205 Structure

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Quality Control & Documentation
Biological Activity

GLPG1205 is potent, selective and orally active GPR84 (a G-protein-coupled receptor) antagonist with a favorable PK/PD profile. GLPG1205 has anti-inflammatory activity and is used for the treatment of pulmonary fibrosis.

Chemical Information
Molecular Weight 378.42
CAS Number 1445847-37-9
Solubility (25°C) DMSO 150 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Helen Timmis, et al. GLPG1205, a GPR84 Modulator: Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects

[2] Julie Desrivot, et al. Effect of GLPG1205, a GPR84 Modulator, on CYP2C9, CYP2C19, and CYP1A2 Enzymes: In Vitro and Phase 1 Studies

[3] Lin-Hai Chen, et al. Modulation of the G-Protein-Coupled Receptor 84 (GPR84) by Agonists and Antagonists

[4] Martina Sundqvist, et al. Similarities and differences between the responses induced in human phagocytes through activation of the medium chain fatty acid receptor GPR84 and the short chain fatty acid receptor FFA2R

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Keywords: GLPG1205 supplier, inhibitors, activators

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