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GLPG0187 treatment significantly (p < 0.05) reduced PC3 cell number within the metatarsal in vivo and reduced migration (p < 0.05) and proliferation (p < 0.05) but not cell viability in vitro. This new model allows evaluation of the early events of tumour-cell homing and localisation to the bone microenvironment, in addition to determining responses to therapeutic interventions.
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Source | Int J Cancer (2015). Figure 3. GLPG0187 |
| Method | cell viability, proliferation, migration assay | |
| Cell Lines | PC3 cell | |
| Concentrations | 50 ng/ml | |
| Incubation Time | 96 hr | |
| Results | GLPG0187 significantly (p<0.05) reduced the number of tumour cells present in the implanted metatarsal from day 17 on ward |
| Molecular Weight | 595.71 |
| Formula | C29H37N7O5S |
| CAS Number | 1320346-97-1 |
| Solubility (25°C) | 10mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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