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(Glp1)-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist. [Pyr1]-Apelin-13 improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats.
| Molecular Weight | 1533.80 |
| Formula | C69H108N22O16S |
| CAS Number | 217082-60-5 |
| Solubility (25°C) | Water |
| Storage | -20°C, sealed |
| Related Apelin Receptor Products |
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| ML221
ML221 is an Apelin (APJ) antagonist and inhibits apelin-13-mediated activation of APJ. IC50 values of cAMP and β -Arrestin were 0.70 μM and 1.75 μM, respectively. EC80 values were all 10 nM. |
| Apelin-13 TFA
Apelin-13 is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. |
| Apelin-36(rat, mouse) TFA
Apelin-36(rat, mouse) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. |
| Elabela(19-32)
Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart. |
| Elabela(19-32) TFA
Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) TFA activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart. |
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