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GLP-26 is an HBV capsid assembly modulators (CAM), inhibits HBV DNA replication (IC50=3 nM) in Hep AD38 system, and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools. GLP-26 (0.7-1.7 μM; 3 days) reduces HBeAg secretion in HepNTCP-DL cells transfected with wild-type HBV, with EC50 values of 0.7 μM.
| Molecular Weight | 373.35 |
| Formula | C19H17F2N3O3 |
| CAS Number | 2133017-36-2 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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