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Girinimbine is a carbazole alkaloid isolated from the plants M. koenigii and Murraya koenigii, with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities. Girinimbine (56 µM; 24-48 h) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells[1]. HepG2 cells. Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid.
| Molecular Weight | 263.33 |
| Formula | C18H17NO |
| CAS Number | 23095-44-5 |
| Solubility (25°C) | DMSO 15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Alkaloids Products |
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Peimine is a natural compound with good anti-inflammatory effects in vivo. |
| Solamargine
Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicinal herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells. |
| Gelsenicine
Gelsenicine |
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