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Giredestrant (GDC-9545) is an orally active, selective estrogen receptor degrader (SERD) with best-in-class potential to compete with estradiol in the ER ligand binding domain and induce conformational changes.Giredestrant has antitumor activity.
| Molecular Weight | 522.55 |
| Formula | C27H31F5N4O |
| CAS Number | 1953133-47-5 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Estrogen Receptor Products |
|---|
| Fulvestrant
Fulvestrant is a Estrogen receptor (ER) antagonist with IC50 of 0.094 nM. Fulvestrant can also induce autophagy and apoptosis, and has anti-tumor effect. |
| LY500307
LY500307 is a potent, selective estrogen receptor beta agonist with an EC50 of 0.66 nM. |
| Calcitriol
Calcitriol is an Active metabolite of vitamin D3 that activates the vitamin D receptor. *The compound is unstable in solutions, freshly prepared is recommended |
| Tamoxifen Citrate (ICI 46474)
Tamoxifen Citrate is an antagonist of the estrogen receptor by competitive inhibition of estrogen binding. |
| 20-Hydroxyecdysone
20-Hydroxyecdysone (Ecdysterone, 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods. |
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Products are for research use only. Not for human use. We do not sell to patients.
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