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GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276. GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s=2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM.
| Molecular Weight | 429.58 |
| Formula | C23H31N3O3S |
| CAS Number | 171744-11-9 |
| Solubility (25°C) | DMSO 50 mg/mL (ultrasonic) |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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