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Geraniin is a TNF-α releasing inhibitor with an IC50 of 43 μM, it has numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities. Geraniin significantly decreases the viability of OVCAR3 and SKOV3 cells in a concentration-dependent fashion. The IC50 value for Geraniin treatment is 34.5±2.8 μM in OVCAR3 cells and 23.6±1.9 μM in SKOV3 cells.
In vivo, oral administration of Geraniin to rats (50 mg/kg/d or 100 mg/kg/d) inhibit the elevation of serum total cholesterol, lipid peroxide, free fatty acid, triglyceride, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase induced by treatment with peroxidized oil.
| Cell Experiment | |
|---|---|
| Cell lines | HepG2 |
| Preparation method | Inhibition of cell proliferation by geraniin was measured by the MTT assay. HepG2 cells were plated in 96-well plates at a density of 1 × 10^4 cells per well. After incubation with medium for 24 h, cells were incubated with indicated concentrations of geraniin for 24 h. |
| Concentrations | 5, 10, 20 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Male BALB/c mice |
| Formulation | 5% DMSO |
| Dosages | 10, 20, 40 mg/kg |
| Administration | Intraperitoneal injection |
| Molecular Weight | 952.64 |
| Formula | C41H28O27 |
| CAS Number | 60976-49-0 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
[5] Erika Moreno, et al. Geraniin is a diuretic by inhibiting the Na +-K +-2Cl - cotransporter NKCC2
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