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Gentamycin (Gentacycol) is an aminoglycoside antibiotic and was isolated from Micromonospora species. Gentamicin sulfate is a strong inhibitor of DNase I with an IC50 value of 0.57 ± 0.12 mM. It is a broad-spectrum cell culture antibiotic that is nontoxic to viruses and mammalian cells at antibacterial and antimycoplasmal concentrations. Its extended stability and slow development of bacterial resistance allow long-term virus and tissue culture studies. It is not used for Neisseria gonorrhoeae, Neisseria meningitidis or Legionella pneumophila bacterial infections (because of the risk of the patient going into shock from lipid A endotoxin found in certain Gram-negative organisms). Gentamicin is also useful against Yersinia pestis and its relatives although need for treatment in most cases is rare, as this bacterium is the one that causes plague.
medicine and pharmacology. 2024 May 2.
Anodic Production and Characterization of Biomimetic Oxide Layers on Grade 4 Titanium for Medical Applications
Gentamicin Sulfate purchased from AbMole
Front Immunol. 2023 Mar 15;14:1127552.
Giardia duodenalis-induced G0/G1 intestinal epithelial cell cycle arrest and apoptosis involve activation of endoplasmic reticulum stress in vitro
Gentamicin Sulfate purchased from AbMole
| Molecular Weight | 575.67 |
| Formula | C21H43N5O7.H2SO4 |
| CAS Number | 1405-41-0 |
| Solubility (25°C) | Water 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Rudin A, et al. Appl Microbiol. Antibacterial activity of gentamicin sulfate in tissue culture.
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