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Genipin is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis. Genipin is a hydrolytic product of geniposide. Genipin has been used in traditional Chinese medicine. Genipin is used in traditional Chinese medicine to relieve the symptoms of type 2 diabetes. Genipin is an excellent natural cross-linker for proteins, collagen, gelatin, and chitosan cross-linking. Genipin has a low acute toxicity, with LD50 i.v. 382 mg/kg in mice. Therefore, much less toxic than glutaraldehyde and many other commonly used synthetic cross-linking regents. Genipin is also used for pharmaceutical purposes, such as choleretic action for liver diseases control. Furthermore，genipin can be used as a cross-linking agent for immobilized enzyme, the regulating agent for compound delivery, the raw materials for gardenia blue pigment preparation,as well as the intermediate for alkaloid synthetic etc. Genipin is a naturally occurring material that shows great potential as a use in biomaterials and also as a fingerprint reagent.
| Molecular Weight | 226.23 |
| Formula | C11H14O5 |
| CAS Number | 6902-77-8 |
| Solubility (25°C) | DMSO 75 mg/mL, Water 3 mg/mL |
| Storage | 2-8°C, protect from light |
[1] Elena Koudouna, et al. Genipin in an Ex Vivo Corneal Model of Bacterial and Fungal Keratitis
[2] Christopher Donovan, et al. Genipin Delays Corneal Stromal Enzymatic Digestion
[5] Muthu K Shanmugam, et al. Potential role of genipin in cancer therapy
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