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Gemcitabine is an antimetabolites, which inhibits DNA synthesis with an IC50 of 0.06 µM. Gemcitabine is a nucleoside analogue that is incorporated into replicating DNA, resulting in partial chain termination and stalling of replication forks.
Cancer Metab. 2025 Feb 10;13(1):7.
FOXO3a/miR-4259-driven LDHA expression as a key mechanism of gemcitabine sensitivity in pancreatic ductal adenocarcinoma
Gemcitabine Hydrochloride purchased from AbMole
Oncol Lett. 2022 May;23(5):163.
AK4P1 is a cancer-promoting pseudogene in pancreatic adenocarcinoma cells whose transcripts can be transmitted by exosomes
Gemcitabine Hydrochloride purchased from AbMole
Int J Oncol. 2020 Jan;56(1):47-68.
Circulating non‑coding RNA‑biomarker potential in neoadjuvant chemotherapy of triple negative breast cancer?
Gemcitabine Hydrochloride purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | BxPC-3, PANC-1 and PaCa-2 cell lines |
| Preparation method | Cell Counts. The cells were plated in 6-well plates. Twenty-four hours later, the cells were treated with vehicle, gemcitabine, DMAPT, or the combination. After 72 h of treatment, trypan blue-excluded cell counts were performed in duplicate using a hemocytometer. Cell growth was expressed relative to vehicle-treated cells (100 %). |
| Concentrations | 0, 0.005, 0.01, 0.02, 0.04 μM |
| Incubation time | 72 h |
| Animal Experiment | |
|---|---|
| Animal models | MIA PaCa-2 Xenografts model in athymic nude mice |
| Formulation | phosphate-buffered saline, PBS |
| Dosages | a single dose of 50 or 100 mg/kg |
| Administration | intraperitoneal injection |
| Molecular Weight | 299.66 |
| Formula | C9H11F2N3O4.HCI |
| CAS Number | 122111-03-9 |
| Solubility (25°C) | Water 30 mg/mL DMSO 50 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
| Related DNA/RNA Synthesis Products |
|---|
| Clofarabine
Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. |
| Nelarabine
Nelarabine is a novel purine antimetabolite antineoplastic agent. |
| Mizoribine
Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. Mizoribine inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively. |
| Capecitabine
Capecitabine is an orally-administered chemotherapeutic agent. Capecitabine is a precursor, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. Capecitabine may inhibit cytochrome CYP2C9 enzyme, and therefore increase levels of substrates such as phenytoin and other substrates of CYP2C9. |
| Temozolomide
Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent. |
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