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Gemcabene

Cat. No. M21472

All AbMole products are for research use only, cannot be used for human consumption.

Gemcabene Structure
Synonym:

PD-72953

Size Price Availability Quantity
5mg USD 135 In stock
10mg USD 210 In stock
25mg USD 420 In stock
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Quality Control & Documentation
Biological Activity

Gemcabene (PD-72953) is a first-in-class PPARα agonist, lipid-lowering agent. It lowers density lipoprotein cholesterol (LDL-C), lowers triglycerides and increases high density lipoprotein cholesterol (HDL-C), and lowers the pro-inflammatory acute phase protein, C-reactive protein (CRP), showing anti-inflammatory activity.

Chemical Information
Molecular Weight 302.41
Formula C16H30O5
CAS Number 183293-82-5
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Smruti M Besekar, et al. Cureus. A Systematic Review of the Randomized Controlled Trials of Gemcabene and Its Therapeutic Uses

[2] Daniel Gaudet, et al. Am J Cardiol. Usefulness of Gemcabene in Homozygous Familial Hypercholesterolemia (from COBALT-1)

[3] Daniela Carmen Oniciu, et al. PLoS One. Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH

[4] Rai Ajit K Srivastava, et al. Mol Cell Biochem. Gemcabene, a first-in-class lipid-lowering agent in late-stage development, down-regulates acute-phase C-reactive protein via C/EBP-δ-mediated transcriptional mechanism

[5] Jaap W Mandema, et al. AAPS J. Model-based development of gemcabene, a new lipid-altering agent

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Keywords: Gemcabene, PD-72953 supplier, inhibitors, activators

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