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GDC-0326

Cat. No. M5255

All AbMole products are for research use only, cannot be used for human consumption.

GDC-0326 Structure
Size Price Availability
5mg USD 110 Custom Synthesis
10mg USD 198 Custom Synthesis
25mg USD 420 Custom Synthesis
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Quality Control & Documentation
Biological Activity

GDC-0326 reduced the incidence of liver and lymph node metastasis compared with vehicle-treated mice. We also demonstrated that tumor and stromal cells are implicated in the antitumor activity of GDC-0326 in RIP1-Tag2 tumors.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models RIP1-Tag2 mice
Formulation
Dosages
Administration i.v.
Chemical Information
Molecular Weight 382.42
Formula C19H22N6O3
CAS Number 1282514-88-8
Solubility (25°C) 10mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Soler A, et al. Clin Cancer Res. Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors.

[2] Heffron TP, et al. J Med Chem. The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).

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Keywords: GDC-0326 supplier, PI3K, inhibitors, activators

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