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GB1107

Cat. No. M9897

All AbMole products are for research use only, cannot be used for human consumption.

GB1107 Structure
Synonym:

GB-1107

Size Price Availability Quantity
10mM*1mL in DMSO USD 340 In stock
1mg USD 125 In stock
5mg USD 295 In stock
10mg USD 470 In stock
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Biological Activity

GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules.

Chemical Information
Molecular Weight 522.32
Formula C20H16Cl2F3N3O4S
CAS Number 1978336-61-6
Solubility (25°C) DMSO 45 mg/mL
Storage -20°C, dry, sealed
References

[1] Lynda Vuong, et al. Cancer Res. An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade

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  Catalog
Abmole Inhibitor Catalog




Keywords: GB1107, GB-1107 supplier, Galectin, inhibitors, activators

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