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Gambogenic acid is the active ingredient in Huangteng and has anti-cancer activity. Gambogenic acid is an effective EZH2 inhibitor, which specifically covalently binds to Cys668 in the EZH2-SET domain to induce EZH2 ubiquitination.
| Molecular Weight | 630.78 |
| Formula | C38H46O8 |
| CAS Number | 173932-75-7 |
| Solubility (25°C) | DMSO ≥ 200 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Related Histone Methyltransferase Products |
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| VTP50469
VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL Interaction with a Ki value of 104 pM. VTP50469 has anti-leukemia activity. |
| BIX 01294 Trihydrochloride
BIX 01294 Trihydrochloride is a potent inhitor of G9a histone methyltransferase with IC50 of 2.7 μM. |
| EBI-2511
EBI-2511 is an orally active, potent inhibitor of EZH2 in Pfeffiera cells IC50 The value is 6 nM. |
| EPZ-5676
EPZ-5676 is a potent and selective aminonucleoside inhibitor of DOT1L histone methyltransferase. |
| EPZ004777
EPZ004777 is a potent, selective, small-molecule inhibitor of DOT1L with IC50 of 0.4 nM. |
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